A novel antiviral strategy by disrupting the equilibrium of virus-host calcium homeostasis
Year: 2025
Type: review
Abstract: Calcium (Ca 2+ ) homeostasis is essential for cellular signaling and protein trafficking. Viruses are comparatively simple organisms that leverage the availability of host cellular mechanisms for viral replication, including the manipulation of cellular Ca 2+ dynamics-related processes. We review the dependence of HIV on cellular Ca 2+ to promote viral replication, including stabilization of viral protein complexes in clinically latent HIV infected cells. We also discuss some of the general reliance of cellular Ca 2+ homeostasis on viral propagation across several viruses. We discuss viral manipulations of cellular Ca 2+ regulation for viral replication, specifically for viral assembly, complex stability, and disassembly. We close with an exploration of therapeutic opportunities via Ca 2+ homeostasis disruption to mediate dysregulation of viral complex formation for viral peptide antigen presentation. Thereby, we aim to unlock a novel strategy to achieve an antiviral effect by modulating host-cell regulatory processes.
Source: Current Opinion in Virology
Institution: Griffith University
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,690
OpenAlex ID: W4416110514