Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND Patients with concurrent acute biliary pancreatitis (ABP) and acute cholangitis (AC) may experience exacerbated clinical consequences due to bile duct stones. However, studies exploring this topic remain limited. AIM To compare the clinical presentation and outcomes of patients experiencing AC with and without ABP. METHODS This single-center retrospective cohort study included 358 patients with AC who underwent endoscopic retrograde cholangiopancreatography (ERCP) between January 2016 and December 2017. Patients were divided into two groups: AC with ABP (n = 90) and AC without ABP (n = 268). Clinical characteristics, laboratory data, ERCP results, primary study outcome [intensive care unit (ICU) admission], and secondary outcomes including 30-day mortality, length of hospital stay, and 30-day readmission rate were analyzed and compared. RESULTS All patients in the AC with ABP group had interstitial pancreatitis. The AC with ABP group had significantly higher white cell count (WBC) counts (13.1 × 10³/µL vs 10.4 × 10³/µL, P = 0.007) and more abnormal WBC results (61.1% vs 42.3%, P = 0.015). Liver biochemical tests, AC severity, ERCP success, adverse events, ICU admissions, 30-day mortality, hospital stay, and readmission rates did not differ significantly between the two groups. Univariate analysis showed no significant link between concurrent ABP and ICU admission, although significance was marginal in moderate/severe ABP cases (P = 0.051). In the multivariate analysis, age (P = 0.035) and cardiovascular dysfunction (P < 0.001) were independently associated with length of ICU stay. CONCLUSION Concurrent interstitial ABP and AC did not significantly affect outcomes. Age and cardiovascular dysfunction were stronger predictors of ICU admission and should guide clinical monitoring and management.
Source: World Journal of Clinical Cases
Authors: Kuan-Ting Liu, Mu-Hsien Lee, Cheng-Hui Lin, Yung-Kuan Tsou, Kai-Feng Sung, Sheng Fu Wang, Chi-Huan Wu, Nai-Jen Liu
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416119907