Work

Biosynthesis and Synthesis of Griseoviridin and Viridogrisein

Year: 2025

Type: article

Abstract: Griseoviridin and viridogrisein are synergistic type A/B streptogramin antibiotics that cooperatively inhibit protein translation in Gram-positive pathogens. This review provides an overview of their discovery and bioactivity and highlights key biosynthetic and synthetic advances that have enabled analog development to address antibiotic resistance. The review is organized into five sections: IntroductionStructural assignment and biological studiesBiosynthesisSynthesisConclusion.

Source: Synthesis

DOI: 10.1055/a-2744-6345

Authors: Leyan Xu, Hans Renata

Institution: Rice University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Applications of Biocatalytic C–H Functionalization in Complex Molecule Synthesis