Work

Zervimesine, a Small Sigma-2 Receptor Selective Modulator for Alzheimer’s Disease

Year: 2025

Type: editorial

Abstract: Zervimesine is a small molecule, able to cross the blood-brain barrier, readily available by straightforward organic chemistry processes, showing few "off-target" effects, but displays a potent and selective S2R modulator profile. Evidence suggests Zervimesine can protect synapses and neurons by preventing the toxic effects of soluble Aβ oligomers.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.5c00653

Authors: Isabel Iriepa, Marialessandra Contino, Carmen Abate, José Marco-Contelles

Institutions: Universidad de Alcalá, University of Bari Aldo Moro, Consejo Superior de Investigaciones Científicas, Instituto de Química Orgánica General

Language: English

Topic: Pharmacological Receptor Mechanisms and Effects

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: European Cooperation in Science and Technology