Work

Succinate Dehydrogenase Pathogenic Variants Among Older Adults With Head and Neck Paragangliomas

Year: 2025

Type: article

Abstract: ABSTRACT Introduction The objective of this study was to determine the proportion of patients over the age of 50 who have HNPGL related to an SDH PV. Methods Patients seen at a single, tertiary‐care academic medical center diagnosed with a new HNPGL over the age of 50 were included and analyzed. Results One hundred and eleven individuals (155 tumors) were included. Eighty (72%) patients underwent genetic testing. Twenty‐one PVs of known significance were identified ( SDHA in 1, SDHB in 11, SDHC in 5, SDHD in 3, and FH in 1). The rate of SDH PVs in the tested group was 25%. The median age in patients with a PV was 60 years (IQR: 54–67) years, compared to 67 years (IQR: 59–71) in those without. Conclusions Patients diagnosed with a HNPGL over the age of 50 are still at risk for having an SDH PV. Older patients with HNPGL and their families should still be referred for genetic testing. Level of Evidence IV.

Source: Laryngoscope Investigative Otolaryngology

DOI: 10.1002/lio2.70302

Authors: Nikhil Bellamkonda, Anne Naumer, Luke O. Buchmann, Hilary C. McCrary, Mana Espahbodi, Neil S. Patel

Institutions: University of Utah, Huntsman Cancer Institute

Language: English

Topic: Adrenal and Paraganglionic Tumors

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,900