Early assessment of treatment response in AML using FLT PET/cT: a trial of the ECOG-ACRIN Cancer Research Group (EAI141)
Year: 2025
Type: article
Abstract: F-fluorothymidine (FLT) PET/CT as a treatment response biomarker. The primary objective was to evaluate the negative predictive value (NPV) of post-treatment 'day 14' FLT-uptake (clinically non-responding patients with high FLT uptake). Among 87 patients enrolled from 9 centers, 61 were evaluable for the primary endpoint. The NPV for FLT PET/CT was 0.20 (3/15, 95% CI 0.04-0.48) compared to the NPV for nadir bone marrow of 0.25 (4/16, 95% CI 0.07-0.52). This first multi-center molecular imaging study in patients with AML demonstrated the feasibility of FLT PET/CT imaging. While molecular imaging did not predict response status more accurately than the nadir marrow, this study showed limitations in the accuracy of the 'day 14' marrow as a predictor of response and suggested added benefit by combining a marrow assessment and molecular imaging at an earlier time point.
Authors: Robert Jeraj, Fenghai Duan, Ryan J. Mattison, Justin Romanoff, Lale Kostakoglu, Daniel A. Arber, Elisabeth M. Paietta, Jennifer L. Holter-Chakrabarty, Charles D. Arnold, Stephen A. Strickland, Jennifer G. Whisenant, Barry A. Siegel, Geoffrey L. Uy, Kebede H. Begna, Gregory A. Wiseman, Aric C. Hall, Scott B. Perlman, Mark R. Litzow, David A. Mankoff
Institutions: University of Wisconsin System, University of Wisconsin–Madison, NYU Langone Health, University of Chicago, Montefiore Medical Center, OU Health Stephenson Cancer Center, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Washington University in St. Louis, Mayo Clinic, University of Pennsylvania
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1557721926, G1588009777, ECOG-ACRIN Network Group Operations Center, MINORITY-BASED COMMUNITY ONCOLOGY PROGRAM, G2284342099, G2304223924, G2819266960, G3053988604, G3100437649, G3121473000, G3475623468, G3857044320, NRG Oncology Network Group Operations Center, G4542188341, G4749780972, G476460321, G5009787934, UG1 - NCTN (Network Lead), G62388112, G6499057061, G6705915398, G7680629189, G8013745456, G8220656038, G8355554651, Vanderbilt Network Lead Academic Participating Site for the NCTN, National Clinical Trials Network Research at the University of Wisconsin, G9000242559, G9000268870, G9000280145, G9000327439, G993993821
OpenAlex ID: W4416128391