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Reference Values for Extended Lymphocyte Subsets in Korean Children: A Multicenter Study Using the EuroFlow PIDOT Panel

Year: 2025

Type: article

Abstract: Background: Current reference intervals for lymphocyte subpopulations are primarily based on Western populations, with limited data available for Korean children, particularly for extended subsets. We determined absolute cell counts and percentages of lymphocyte subpopulations in Korean children, according to age and sex. Methods: subsets; T and B cells were further subdivided according to their maturation stage. Results: central memory/transitional memory T cells. Conclusions: To the best of our knowledge, this study is the first to establish reference values for extended lymphocyte subsets in Korean children using the PIDOT panel. Age, sex, and laboratory-related factors influenced lymphocyte subset distributions. These findings may serve as reference data for immune disorders and immunotherapy in pediatric populations.

Source: Annals of Laboratory Medicine

DOI: 10.3343/alm.2025.0241

Authors: Kyung-Hwa Shin, Hyun-Woo Choi, Jihyang Lim, Eun-Suk Kang

Institutions: Pusan National University Hospital, Pusan National University, Chonnam National University, Chonnam National University Hospital, The Catholic University of Korea Eunpyeong St. Mary's Hospital, Catholic University of Korea, Samsung Medical Center, Sungkyunkwan University

Language: English

Topic: Clinical Laboratory Practices and Quality Control

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416129089

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