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Methylated regioisomers of Re( i ) and Ir( iii ) tetrazole complexes: photophysical properties and optical imaging of brain tissue

Year: 2025
Type: article
Abstract: 1-methylated complexes in all cases display a significant redshift in the emission band. The shift is ascribed to a stabilisation of the π* orbitals of the tetrazole ligands, which is also supported by cyclic voltammetry and time-dependent density functional theory (TD-DFT) calculations. The complexes were used as luminescent labels for the staining of mouse brain tissue. The Re(I) complexes did not show any evident staining. On the other hand, the Ir(III) complexes - particularly those bound to the ligand containing the quinoline substituent - demonstrated affinity for lipid-rich myelinated regions in brain tissues and white matter in cerebellum tissues. The specificity of the Ir(III) complexes was further demonstrated by means of correlative optical microscopy and Fourier transform infrared (FTIR) microscopy.
DOI: 10.1039/d5dt01745a
Authors: Elena Dallerba, Lee J. Cameron, Blake I. Armstrong, Gaewyn Ellison, Eva Turner, Evelyn S. Innes, Georgia L. Strickling, Joel Pangiarella, Peter Ó. Conghaile, Michael Nesbit, Stephen A. Moggach, Paolo Raiteri, Stefano Stagni, Emma L. Pearson, Mark J. Hackett, Massimiliano Massi
Language: English
Open Access status: green
Funders: National Computational Infrastructure, Multiple Sclerosis Australia, Australian Institute of Nuclear Science and Engineering, Curtin University of Technology, Government of Western Australia, Australian Research Council, Curtin Health Innovation Research Institute, Curtin University
OpenAlex ID: W4416129714
FWCI: 0.207
Cites: 47
Cited by: 1
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