Work

A clinical report and analysis of metachronous multiple primary cancers occurred in four sites

Year: 2025

Type: article

Abstract: PURPOSE: This case report describes a rare occurrence of quadruple primary malignancies-specifically, bilateral primary breast cancer, ovarian cancer, and pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma-and explores its potential association with hereditary tumor syndromes. METHODS: We conducted a detailed clinical and histopathological analysis of the case. Repeated imaging and pathological examinations were performed to confirm the diagnosis of each primary malignancy. RESULTS: The patient was diagnosed with four distinct primary tumors, and pathological evaluation confirmed each malignancy. CONCLUSION: This case emphasizes the importance of comprehensive pathological and genetic evaluation in patients with multiple primary malignancies. It highlights the growing incidence of such tumors among long-term cancer survivors and provides valuable insights for diagnosis and management in the context of hereditary cancer syndromes.

Source: Journal of Cancer Research and Clinical Oncology

DOI: 10.1007/s00432-025-06354-z

Authors: Rongze Sun, Hongxia Xie, Sijia He, Qi Li

Institutions: Shanghai Jiao Tong University, Shanghai First People's Hospital

Language: English

Topic: Multiple and Secondary Primary Cancers

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,390