Work

Effect of fluid balance situation within 7 days and early fluid intake after admission to the intensive care unit on in-hospital mortality and 1-year mortality in patients with cardiac arrest: a retrospective study from the MIMIC IV database

Year: 2025

Type: article

Abstract: Background The objective of this study was to assess the associations between the mean daily fluid balance within 7 days and fluid intake within 24 h after admission to intensive care unit (ICU) and mortality for hospitalization and 1-year in cardiac arrest (CA) patients. Methods Patients who experienced CA were enrolled from the Medical Information Mart for Intensive Care Database. CA patients were divided into <14, 14–37, 38–79 and >79 ml.kg −1 groups according to the interquartile range of the mean daily fluid balance. In addition, patients were divided into low (<147 ml.kg −1 ) fluid intake group and high (≥147 ml.kg −1 ) fluid intake group according to the median fluid intake within 24 h after admission to the ICU. Multivariate logistic regression models were constructed to determine the independent risk factors for in-hospital mortality and 1-year mortality. Results The in-hospital mortality in the 38–79 ml.kg −1 and the >79 ml.kg −1 groups were higher than in the 14–37 ml.kg −1 and the <14 ml.kg −1 groups ( P < 0.05). The 1-year mortality in the 38–79 ml.kg −1 and the >79 ml.kg −1 groups were higher than in the <14 ml.kg −1 group ( P < 0.05). The 38–79 ml.kg −1 and >79 ml.kg −1 groups were associated with increased risk of in-hospital mortality [odds ratio (OR) 2.300, 95% confidence interval (CI) 1.381–3.831; P = 0.001; OR 2.691, 95% CI 1.515–4.779; P = 0.001] and 1-year mortality (OR 2.131, 95% CI 1.308–3.470; P = 0.002; OR 2.141, 95% CI 1.237–3.703; P = 0.006). The in-hospital mortality in the high-fluid intake group was higher than in the low-fluid intake group ( P < 0.05). The 1-year mortality was not significantly different between the two groups ( P = 0.055). A high fluid intake was not associated with an increased risk of in-hospital mortality (OR 0.841, 95% CI 0.587–1.204; P = 0.344). Conclusion Mean daily fluid balance ≥38 ml.kg −1 within 7 days after admission to the ICU was associated with increased in-hospital mortality and 1-year mortality in cardiac arrest patients. Fluid intake ≥147 ml.kg −1 within 24 h after admission to the ICU was not associated with increased in-hospital mortality in cardiac arrest patients.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2025.1519306