Work

The interplay between metabolism and neuroinflammation in epilepsy: mechanisms and therapeutic perspectives

Year: 2025

Type: article

Abstract: Emerging evidence underscores the critical role of neuroinflammation and metabolism in the pathophysiology of epilepsy. Metabolic dysregulation and neuroinflammation exacerbate each other, creating a vicious cycle. Although this interplay offers novel insights into the mechanisms underlying neurological disorders and potential therapeutic approaches, its role in epilepsy remains unclear. In this study, we review the interplay between metabolism and neuroinflammation, focusing on glucose, glutamate /γ-aminobutyric acid (GABA), tryptophan-kynurenine, adenosine, and lipid metabolism, aiming to contribute to the development of innovative therapeutic strategies for epilepsy. We also discuss the potential anti-neuroinflammatory and antiepileptic effects of metabolic therapies.

Source: Journal of Neuroinflammation

DOI: 10.1186/s12974-025-03553-w

Authors: Leqing Xu, Zhao Zhao, Yufei Zhang, Chunlai Ma

Institutions: Fudan University, Huashan Hospital

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,090