Work

Kill Two Birds with One Stone: An Efficient and Potent AR CBS-Targeted Degrader Reverses Breast Cancer Resistance via Concurrent AR Degradation and ERα Transcriptional Suppression

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c01926

Authors: Yihe Wu, Baohua Xie, Jinsen Liang, Dongmei Wei, Yubo Wang, Yudong Yin, Xiaofei Deng, Chao Wang, Jian Ni, Lanxin Yang, Chune Dong, Xin Han, Hai-Bing Zhou

Institutions: Wuhan University, Zhongnan Hospital of Wuhan University, Second Affiliated Hospital of Zhejiang University, Zhejiang University, State Key Laboratory of Virology

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities

Awards: G5107246530, G6661411643, G7499866166, G8194903517, G8320483035, G8598445767, G8602980873

OpenAlex ID: W4416140621

FWCI: 0.261

Cites: 62

Cited by: 1

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