Work

Rational Design and Biological Evaluation of a Novel Polθ Polymerase Inhibitor for Synergistic Targeting of HR-Deficient Cancers

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c00818

Authors: Ziheng Yu, Zhen Li, Zhen Li, Lei Jiang, Yibin Zhang, Jingxue Zhang, Lu Liu, Ying Qu, Yuchen Wei, Mengying Li, Tao Lu, Zhengtao Li, Zhengtao Li, Yadong Chen, Jie Feng

Institutions: China Pharmaceutical University, Simcere Pharmaceutical (China)

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: National Natural Science Foundation of China

Awards: G3805667187, G8395707685

OpenAlex ID: W4416140651

FWCI: 0.72

Cites: 37

Cited by: 2

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