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Subcallosal Cingulate Deep Brain Stimulation and Heart Rate Variability in Treatment-Resistant Depression: Evidence for Person-Specific Autonomic Phenotypes

Year: 2025

Type: preprint

Abstract: Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an established intervention for treatment-resistant depression (TRD) that modulates white-matter tracts within the central autonomic network (CAN). In eight patients with TRD, SCC DBS produced robust antidepressant effects but no group-level change in heart-rate variability (HRV), a marker of vagal flexibility. However, patients whose mood and HRV covaried over time showed greater HRV improvement, suggesting that SCC DBS enhances autonomic flexibility only in individuals with intact mood–vagal coupling.

DOI: 10.31234/osf.io/rxzmd_v1

Authors: Jacob Francis Dahill-Fuchel, John JB Allen, Elisa Xu, Tanya Nauvel, Jacqueline Overton, Christopher Rozell, Patricio Riva Posse, Martijn Figee, Richard Lane, Helen Mayberg, Allison Waters

Institution: University of Arizona

Language: English

Topic: Neurological disorders and treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4416150220

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