Work

Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease

Year: 2025

Type: article

Abstract: Inflammatory bowel disease (IBD), a chronic disorder characterized by intestinal inflammation and mucosal damage, includes mainly Crohn's disease and ulcerative colitis. However, the cause of its onset remains unclear. The pathogenesis of IBD is closely related to host genetic susceptibility, disorders of the intestinal flora, damage to the intestinal mucosal barrier, and abnormal intestinal mucosal immunity. On the basis of the progress in research on the structure of the intestinal microbiota involved in IBD, the influence of genetics on the intestinal barrier and intestinal microbiota; the metagenomics, metatranscriptomics, and metabolomics of the intestinal microbiota involved in IBD; and treatments such as probiotics and fecal microbiota transplantation are important for the future treatment of IBD and the development of drugs for effective treatment.

Source: World Journal of Gastroenterology

DOI: 10.3748/wjg.v31.i42.113170

Authors: Lie Zheng, Sheng-Lei Duan, Kai Wang

Institutions: Shaanxi Provincial Hospital of Traditional Chinese Medicine, Second Peoples Hospital of Shaanxi Province

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Institut National de la Recherche Agronomique, European Regional Development Fund