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Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice

Year: 2025

Type: article

Abstract: This letter addresses Pravda's innovative review, which proposes hydrogen peroxide as the primary pathogenic factor in ulcerative colitis (UC). Although the author presents intriguing mechanistic insights and reports encouraging clinical outcomes with reducing agents, several methodological and clinical considerations require discussion. We examine three key aspects: The selective evidence synthesis approach; the need for rigorous clinical validation of proposed therapies; and the integration of this novel hypothesis with established inflammatory bowel disease pathogenesis. Given the complexity of UC, future therapeutic advances may require collaborative approaches that integrate redox-based mechanisms into existing evidence-based frameworks rather than replacing current paradigms.

Source: World Journal of Gastroenterology

DOI: 10.3748/wjg.v31.i42.112566

Authors: Xiao-Yu Wang, Fan An, Ben-Jun Wang, Wei-Wei Han

Institutions: Shandong University of Traditional Chinese Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4416156253