Work

Diversifying the triquinazine scaffold of a Janus kinase inhibitor

Year: 2025

Type: article

Abstract: Diversifying the sp 3 -rich triquinazine core, we prepared four new chiral scaffolds and 26 analogues that reveal how subtle structural changes modulate Janus Kinase activity, yielding a potent JAK1 inhibitor comparable to FDA-approved drugs.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00921a

Authors: Kleni Mulliri, Kris Meier, Johanna-Dorothea Feuchter, Sacha Javor, Matheus A. Meirelles, Jean-Louis Reymond

Institution: University of Bern

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Award: Chemical Space Inspired Building Blocks and Peptides for Medicinal Chemistry