Work

Comparison of Acute Kidney Disease Staging by Estimated Glomerular Filtration Rate and by Serum Creatinine Ratio in Patients With Dialysis-requiring Acute Kidney Injury: A National Cohort Study From Taiwan

Year: 2025

Type: article

Abstract: Rationale & Objective: ), remains uncertain. Our objective is to assess the predictive ability of these staging systems concerning outcomes. Study Design: Population-based retrospective observational cohort study. Setting & Participants: In total, 40,849 hospitalized patients with acute kidney injury requiring dialysis between July 1, 2015 and June 30, 2022, in the Taiwan National Health Insurance Research Database. Tests Compared: ). Cox proportional hazard models were constructed to examine associations between AKD stages and outcomes. Outcomes: Mortality and sustained kidney recovery. Results: staging system, hazard ratios and 95% confidence intervals for mortality across ascending stages were 0.84 (0.75-0.94), 0.90 (0.77-1.04), 0.93 (0.75-1.16), and 4.32 (4.18-4.47). Subgroup and sensitivity analyses yielded consistent results. Limitations: Retrospective analysis based on a claims database. Conclusions: staging system in patients with acute kidney injury requiring dialysis regarding all-cause mortality and kidney recovery. Future investigations are warranted to evaluate the comparative efficacy in patients with acute kidney injury not requiring dialysis.

Source: Kidney Medicine

DOI: 10.1016/j.xkme.2025.101123