Work

Akt inhibition enhances the antitumor efficacy of immune checkpoint blockades and radiotherapy in a syngeneic breast cancer model

Year: 2025

Type: article

Abstract: DC frequency and reduced monocytic myeloid-derived suppressor cells (M-MDSCs). These findings suggest that addition of an Akt inhibitor to RT and ICBs leads to a less immunosuppressive tumor microenvironment by modulating myeloid cells. Taken together, Akt inhibition could be a viable strategy to overcome therapeutic resistance of ICBs and RT in breast cancer.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2025.201087

Authors: Nawon Park, Seung Hyuck Jeon, Yoomin Kim, Seongmin Kim, In Ah Kim

Institutions: Seoul National University, Seoul National University Bundang Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900