Year: 2025
Type: article
Abstract: In this issue of Blood, Bonal et al 1 report on a mouse model of JAK2V617Fmutant myeloproliferative neoplasm (MPN) induced by low-level chimerism following bone marrow transplantation (BMT) of JAK2V617F cells into unconditioned homeostatic recipient mice.Using this approach that mimics somatically acquired clones in patients, the authors found that these JAK2V617F cells significantly affect both the recipient's BM microenvironment and unmutated naïve hematopoiesis, thereby skewing the recipient's nonmutant hematopoietic system toward an MPN-like phenotype.These findings will have major implications for MPN therapy.
Source: Blood
Authors: Martin Zenke, Steffen Koschmieder
Institution: RWTH Aachen University
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4416186532