Work

Increased alveolar tissue destruction in a sub-group of COPD patients with increased alveolar septal eosinophil counts

Year: 2025

Type: article

Abstract: Background: Higher blood eosinophil counts are associated with greater lung function decline in patients with COPD, and a relationship between higher sputum eosinophil counts and greater emphysema has been reported. The aim of the current study was to investigate a role for eosinophils in alveolar septal damage, which may contribute to emphysema and lung function decline in COPD patients. Methods: 27 smokers and 15 nonsmokers and examined the relationship between eosinophil numbers and alveolar tissue damage using histology techniques. Results: The numbers of ASEC were greater in COPD compared to controls (p≤0.02), and there was a significant correlation between ASEC and alveolar septal damage in a subgroup of COPD patients (rho=0.4, p=0.03). Conclusion: This association suggests a role for eosinophils in the pathogenesis of emphysema in a subset of COPD.

Source: ERJ Open Research

DOI: 10.1183/23120541.00797-2025

Authors: Andrew Higham, Sophie Booth, Josiah Dungwa, Anna Ioannidi, Dave Singh

Institutions: University of Manchester, Manchester University NHS Foundation Trust, Medicines Evaluation Unit

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $808