Work

Immune Checkpoint Inhibitor-Associated Uveitis: Predictors and Survival Impact

Year: 2025

Type: article

Study design: Observational Study

Abstract: In 5966 patients treated with immune checkpoint inhibitors, uveitis was rare (0.49%) but linked to combination therapy, greater cumulative exposure, and prior uveitis. Uveitis occurrence was correlated with longer survival, suggesting heightened systemic immune activation.

Source: Ophthalmology Retina

DOI: 10.1016/j.oret.2025.11.001

Authors: Leila Chew, Jeffrey Feng, Elizabeth Hutchins, Ashley F. Stein-Merlob, Eric H. Yang, Melissa G. Lechner, Edmund Tsui

Institutions: University of California, Los Angeles, UCLA Health

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,920

Funders: Research to Prevent Blindness, National Institutes of Health

Awards: Mechanisms of Thyroid Autoimmunity in Checkpoint Immunotherapy, Identifying new immunotherapeutic targets for endocrine autoimmunity.

OpenAlex ID: W4416189719

FWCI: 2.879

Cites: 7

Cited by: 8

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