Research on Mechanism of Microenvironment of Myeloma Being Restored by Allicin Regulating the Activity of Hedgehog Pathway Through miR-29b
Year: 2025
Type: article
Abstract: Background The proliferation of myeloma cells could be affected partly by the interaction between microRNA-29b (miR-29b) and Hedgehog. Purpose The research on the mechanism of microenvironment of myeloma being restored by allicin, regulating the activity of Hedgehog pathway through miR-29b, was studied to develop theoretical evidence on the drug discovery for myeloma. Materials and Methods A model of mice with myeloma was established. They were divided into several groups, including a model group, a group with a low dose of allicin, a group with a medium dose of allicin, a group with a high dose of allicin, a Neurodazine group, a GDC-0449 group, and a group with a high dose of allicin and Neurodazine. The presentation of the related gene protein was detected, respectively. Results Presentation of the miR-29b gene was increased in groups with different doses of allicin. The presentation of miR-29b gene was increased notably in a group with a high dose of allicin and Neurodazine. Necrosis degree of tumor cells was improved partly through hematoxylin and eosin (H&E) coloration. The presentation of interferon gamma (IFN-γ) was increased, and the presentation of interleukin-17 (IL-17) was decreased. The activity of the Hedgehog pathway could be regulated by allicin through increasing the presentation of miR-29b. So, the microenvironment of myeloma could be improved. Conclusion Hedgehog could be activated by allicin through increasing the presentation of miR-29b. The growth of tumor cells could be restrained. The apoptosis of tumor cells could be promoted. So, the microenvironment of myeloma could be improved.
Source: Pharmacognosy Magazine
Authors: Yanli Wang, Fen Xie, Ying Cai, Ping Xiang
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $1,600
OpenAlex ID: W4416190371