Work

Human Papillomavirus Infection as a Rare Etiological Factor in Moderate Squamous Dysplasia of the Trachea

Year: 2025

Type: article

Abstract: We report the case of a 42-year-old, non-smoking male admitted with right upper-lobe pneumonia. Chest computed tomography (CT) demonstrated findings consistent with an infectious process. For further evaluation, serial bronchoscopies with biopsy sampling were performed. Histopathological examination revealed moderate squamous dysplasia of the tracheal epithelium, and subsequent immunohistochemical testing detected human papillomavirus (HPV) genotype 45. This case underscores the value of integrating imaging, endoscopic assessment, and molecular diagnostic techniques in the evaluation of atypical pulmonary lesions and highlights the potential role of HPV infection in airway epithelial dysplastic changes.

Source: Diagnostics

DOI: 10.3390/diagnostics15222868

Authors: Dana-Maria Avasilcăi, Mihai Arghir, Ancuța-Alina Constantin

Institutions: Carol Davila University of Medicine and Pharmacy, Institutul de Pneumoftiziologie "Marius Nasta"

Language: English

Topic: Tracheal and airway disorders

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137