Year: 2025
Type: editorial
Abstract: show how pollution acts not only as an irritant or trigger, but as a true biological amplifier of sensitization -a concept with both historical and modern mechanistic foundations.Shusterman reconstructs the intellectual lineage of the pollutant-adjuvant concept "From Allergy versus Irritation to Adjuvancy: Lessons from History". Beginning with Japanese and Californian studies from the 1980s, he recounts how diesel exhaust particles enhanced allergen-specific IgE responses and even induced sensitization to new, otherwise innocuous antigens. Subsequent decades broadened this paradigm: second-hand smoke, wood-smoke, formaldehyde, phthalates, and ozone-limonene reaction products all demonstrated adjuvant-like effects.In "The Modern Scene: Pollution and Rhinitis as Markers of the Anthropocene", In conclusion, from diesel exhaust to indoor formaldehyde, from genomic susceptibility to climate-driven pollen shifts, these studies argue that pollution is an active participant in allergic diseases. The airway epithelium translates chemical and biological stressors into inflammation and sensitization. Understanding and mitigating these interactions will define the next decade of respiratory-allergy prevention.
Source: Frontiers in Allergy
Institutions: Universidade Federal do Paraná, Universidad Católica de Salta
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,077
OpenAlex ID: W4416192953
Cites:
Cited by:
Related to: