Ophthalmic and uterine artery dopplers in the second trimester for prediction of preeclampsia
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: The objective of this study was to determine the predictive value of ophthalmic and uterine artery Dopplers in the second trimester for predicting preeclampsia. METHODS: This was a prospective study conducted at the Maternal-Fetal Medicine Unit of King Chulalongkorn Memorial Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Ophthalmic and uterine artery Dopplers were performed at a gestational age of 18-22 weeks. The peak systolic velocity (PSV) ratio of the ophthalmic artery and the mean pulsatility index (PI) of the uterine artery were used to assess the sensitivity and specificity in predicting preeclampsia. RESULTS: A total of 259 pregnant women were enrolled in the study, of whom 15 (5.8%) developed preeclampsia. An ophthalmic artery PSV ratio greater than 0.55 demonstrated a sensitivity of 80.0% for predicting preeclampsia, with a specificity of 51.9%, a positive predictive value (PPV) of 12.8%, and a negative predictive value (NPV) of 98.3%. For the uterine artery PI above the 95th percentile, the sensitivity, specificity, PPV, and NPV were 13.3%, 94.7%, 13.3%, and 94.7%, respectively. When either the ophthalmic artery PSV ratio or the uterine artery PI was used to predict preeclampsia, the sensitivity, specificity, PPV, and NPV for predicting preeclampsia were 86.7%, 63.9%, 12.9%, and 98.7%, respectively. CONCLUSION: The combination of ophthalmic and uterine artery Dopplers between 18 and 22 weeks of gestation exhibited good sensitivity for predicting preeclampsia. This combined approach may be adopted for preeclampsia prediction.
Authors: Padungsak Chanworrawoot, Vorapong Phupong
Institution: Chulalongkorn University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416196968