Adenosine in the Brain: Recent Progress on Detection, Function, and Translation
Year: 2025
Type: article
Abstract: Although adenosine was identified in the brain many decades ago, our understanding of when, where, and how it functions has expanded rapidly in recent years, driven in part by innovative technological advances. Adenosine is now increasingly recognized as a key neuromodulator that dynamically regulates brain circuits important for sleep/wakefulness, movement, cognition, and homeostasis. In addition, growing attention has been directed toward the molecular mechanisms governing adenosine production and its downstream signaling pathways, both of which hold great promise as therapeutic targets for neuropsychiatric disorders and neurodegenerative diseases. This review highlights recent progress in detecting adenosine, unraveling its signaling pathways in vitro and in vivo, and understanding how it regulates brain function under physiological and pathological conditions.
Source: Journal of Neuroscience
Institutions: Oregon Health & Science University, Vollum Institute, Icahn School of Medicine at Mount Sinai, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Rockefeller University, University of Oxford, Aligning Science Across Parkinson's, University of Lisbon, Gulbenkian Institute for Molecular Medicine, Chinese Academy of Sciences, Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences, Wenzhou Medical University
Language: English
Subfield: Physiology
Domain: Life Sciences
Open Access status: hybrid
Awards: G1173444014, G5513954718
OpenAlex ID: W4416196974