Work

Polidocanol Sclerotherapy in Hereditary Hemorrhagic Telangiectasia Patients Does Not Seem to Decrease Epistaxis‐Related Outpatient and Emergency Visits—A Retrospective View

Year: 2025

Type: article

Abstract: IntroductionHereditary hemorrhagic telangiectasia (HHT) is a rare inherited disease characterised by the presence of telangiectasia in the nasal and gastric mucosa and arteriovenous malformations (AVM) in the lungs, brain, and liver [1].All known gene defects underlying the disease are related to the endothelial transforming growth factor beta family.These mutations in HHT patients lead to unregulated vessel wall regeneration in mucous membranes and internal organs leading to activation of angiogenesis.This results in dilated and tortuous postcapillary veins that eventually join the dilated arteries via capillaries.Subsequently, the capillary segments disappear and direct arteriovenous connections are formed [2,3].

Source: Clinical Otolaryngology

DOI: 10.1111/coa.70059

Authors: Elsa‐Leea Kotola, Johanna Wikstén, Eeva Castrén

Institutions: University of Helsinki, Helsinki University Hospital

Language: English

Topic: Vascular Anomalies and Treatments

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,520