Work

Near-infrared photoimmunotherapy for effective elimination of ovarian cancer cells by inducing immunogenic cell death

Year: 2025

Type: article

Abstract: values of ∼42-283 nM. Moreover, all examined NIR-PIT agents induced cell death with efficiencies of ∼80%-92%. The NIR-PIT agents triggered major hallmarks of immunogenic cell death like cell surface expression of calreticulin, HSP70, and HSP90 and the extracellular release of ATP and HMGB1. Furthermore, co-culturing immature dendritic cells with dying cancer cells targeted by EGFR and TF NIR-PIT agents mediated enhanced dendritic cell maturation, as indicated by increased expression of CD80, CD86, CD40, and HLADR. Taken together, our results suggested that all five investigated NIR-PIT agents have great potential to be applicable for ovarian cancer treatment.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2025.201086