Work

From bench to batch: scaling up copper-67 production via the 70 Zn(p,α) 67 Cu nuclear reaction

Year: 2025

Type: article

Abstract: In this work, we present a novel radiochemical separation method for isolating radiocopper from zinc targets, in particular optimized for use in compact cyclotron systems for 67 Cu production from 70 Zn. We further report – for the first time using compact cyclotrons – 67 Cu yields in the GBq range, with molar activities reaching 5–35 % of the theoretical maximum. In addition, high radionuclidic purities comparable to previously described values are presented (>99 %). The complete workflow, including target preparation, irradiation parameters, post-irradiation handling, and quality control, is described in detail, offering a robust and reproducible framework for advancing a reliable 67 Cu production in decentralized settings.

Source: Radiochimica Acta

DOI: 10.1515/ract-2025-0083

Authors: Santiago Andrés Brühlmann, Martin Walther, Nadiya Zhutova, Klaus Kopka, Martin Kreller

Institutions: Helmholtz-Zentrum Dresden-Rossendorf, University Hospital Carl Gustav Carus, Nationales Centrum für Tumorerkrankungen Dresden, German Cancer Consortium (DKTK) Dresden, Technische Universität Dresden

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $2,712

OpenAlex ID: W4416198697

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Cites: 41

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