Monophasic Synovial Sarcoma in an Adolescent: A Great Mimicker of Benign Pathology
Year: 2025
Type: article
Study design: Case Report
Abstract: Monophasic synovial sarcoma (SS) is a rare and aggressive soft-tissue malignancy that can often resemble benign conditions, making diagnosis challenging. A 13-year-old girl presented with a painless, gradually enlarging swelling in the proximal lower extremity for 4 months. Clinical examination revealed a firm, well-defined, deep-seated swelling, and imaging initially indicated a benign spindle-cell tumor, likely a schwannoma. En bloc excision of the mass was done. Histopathology and immunohistochemistry (positive for TLE1 and BCL2) revealed the diagnosis of monophasic SS. Adjuvant chemotherapy and radiotherapy were given. This case highlights the importance of maintaining a high index of suspicion for malignancy in deep-seated soft-tissue tumors. Early diagnosis, complete surgical removal, and multimodal therapy are crucial for the management of SS.
Authors: Sunita Singh, Akshay Kumar, Rohit Kapoor, Divya Prakash, Harshit Bajpayee
Institution: All India Institute of Medical Sciences
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416199707