Work

Platelet stiffness correlates inversely with platelet volume during expansion and compression

Year: 2025

Type: article

Abstract: . We then confirmed this inverse relationship by measurements of platelets during two additional, physiologically highly relevant situations: The dynamic spreading of platelets on a surface and platelets subjected to a spatial confinement, where a decrease in volume was also accompanied by an increase in stiffness and platelets subjected to spatial confinement showed a significantly larger volume compared to unconfined platelets, with a correspondingly lower stiffness, respectively. In conclusion, our SICM analysis revealed a universal, inverse correlation between platelet stiffness and volume change, opening up new perspectives in platelet research.

Source: Soft Matter

DOI: 10.1039/d5sm00839e

Authors: Konstantin Krutzke, Jan Seifert, Meinrad Gawaz, Tilman E. Schäffer, Johannes Rheinlaender

Institution: University of Tübingen

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: Deutsche Forschungsgemeinschaft

Awards: G228917703, G3125489022, GRK 2381: cGMP: Vom Krankenbett an die Laborbank, G5637492803, TRR 240: Thrombozyten – molekulare, zelluläre und systemische Funktionen unter physiologischen und pathologischen Bedingungen