Work

Spleen tyrosine kinase signaling in myeloid cells promotes macrophage infiltration, glomerulosclerosis, and interstitial fibrosis in diabetic kidney disease

Year: 2025

Type: article

Abstract: Spleen tyrosine kinase (SYK) was shown to be mainly expressed by infiltrating kidney macrophages in human and experimental diabetic kidney disease (DKD), suggesting a potential role for SYK in the progression of this disease. Furthermore, myeloid Syk deletion suppressed macrophage recruitment, expression of macrophage elastase ( Mmp-12), and development of glomerular and interstitial fibrosis in a mouse model of hypertensive DKD.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00289.2025

Authors: Xiu Xian Chia, Elyce Ozols, David J. Nikolic-Paterson, Gregory H. Tesch

Institutions: Monash Medical Centre, Monash University

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Diabetes Australia, Monash University