Work

Transcriptome profiling suggests molecular sexual dimorphism in lumbosacral dorsal root ganglia and sex-specific mechanisms underlying visceral pain

Year: 2025

Type: article

Abstract: This study examined transcriptomics in the lumbosacral DRG in a VEGF-induced visceral pain mouse model. Male and female mice underwent intravesical instillations of VEGF 165 or saline. Across the four experimental groups, we found significant sex differences in DRG transcriptome between control animals and VEGF-induced molecular changes, suggesting sex-specific visceral pain mechanisms. These findings provide insight into potential targets for alleviating visceral pain symptoms when considering sex as a biological variable.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00066.2025

Authors: Sathish Kumar Yesupatham, Anna P. Malykhina, Alison Xiaoqiao Xie

Institution: University of Colorado Anschutz

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases