Dendritic Cells: Orchestrators of Immune Responsiveness and Tolerance
Year: 2025
Type: review
Abstract: Dendritic cells (DCs) are central regulators of the delicate balance between protective immune responses to pathogens and cancer, and immunopathology. This review explores the phenotypic and functional heterogeneity of DCs and their specialized roles in regulating the immune response, with a focus on pathways that confer tolerogenic properties to DCs. Furthermore, we discuss emerging strategies for the therapeutic induction of a tolerogenic phenotype in DCs in the setting of autoimmune diseases. A better understanding of the molecular mechanisms that control the tolerogenic phenotype of DCs may open new avenues for the development of efficacious and safe immunotherapies for autoimmune, allergic, and chronic inflammatory diseases.
Source: Immunological Reviews
DOI: 10.1111/imr.70073
Authors: Carolina M. Polonio, Aline N. Qualiotto, Letícia T. da Silva, Francisco J. Quintana
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: American Cancer Society, National Multiple Sclerosis Society, International Progressive MS Alliance, Multiple Sclerosis Society, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences
OpenAlex ID: W4416202870