Work

Multiple [18-F]-Fluorodeoxyglucose-Avid Dermatofibromas Mimicking Cutaneous Metastasis: A Case Report Highlighting a Diagnostic Pitfall in Dermatology

Year: 2025

Type: article

Abstract: Introduction: Dermatofibromas are benign skin tumors that are typically diagnosed clinically without the need for biopsy. While they are not commonly associated with PET imaging findings, they have been occasionally reported to exhibit FDG uptake in radiology literature. However, this remains significantly underrecognized by many dermatologists. Case Presentation: We describe a 42-year-old woman with a history of HER2-positive breast cancer who underwent PET-CT for surveillance. Multifocal FDG-avid nodules were noted and initially interpreted as possible cutaneous metastases. Dermatologic evaluation revealed longstanding, stable papules consistent with dermatofibromas. Biopsy was deferred due to classic features and diagnostic certainty. Conclusion: Dermatofibromas can appear hypermetabolic on PET imaging due to histiocytic and inflammatory cell activity. Awareness of this pitfall is important for dermatologists involved in the care of oncology patients, as recognition may prevent unnecessary biopsies, oncologic escalation, and patient anxiety.

Source: Case Reports in Dermatology

DOI: 10.1159/000549463

Authors: Allison Chiou, Eamonn Maher

Institution: University of Minnesota

Language: English

Topic: Soft tissue tumor case studies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030