Work

UV Spectrophotometric Method for Simultaneous Marketed Brand Gibtulio Met Fixed Dose Combination Tablets

Year: 2024

Type: article

Abstract: A validated UV spectrophotometric method has been developed for the simultaneous quantification of Gibtulio Met (12.5/500mg) Fixed Dose Combination dosage forms using the simultaneous equation method. This approach is based on measuring the absorbance of Metformin HCl and Empagliflozin within the concentration ranges of 2-10 μg/ml and 0.1-5 μg/ml, respectively, at their respective λ max values of 235 nm and 225 nm. The linearity correlation coefficients for Metformin HCl and Empagliflozin in these concentration ranges were 0.999, and 0.9998 respectively. The results were statistically validated in compliance with ICH guidelines. Keywords: Metformin, Empagliflozin, ICH guidelines

Source: Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v23.4.99

Authors: Shailesh B Patil, Jitendra D More

Institution: Kavayitri Bahinabai Chaudhari North Maharashtra University

Language: English

Topic: Analytical Methods in Pharmaceuticals

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416208147