Work

BAFF in autoimmune kidney diseases: pathogenic pathways, biomarker potential, and therapeutic horizons

Year: 2025

Type: article

Abstract: Autoimmune kidney diseases usually arise from autoimmune system dysfunction and are characterized by production of autoantibodies. Several autoimmune kidney diseases are currently recognized, including lupus nephritis, antineutrophil cytoplasmic antibody-associated vasculitis, membranous nephropathy, IgA nephropathy. B-cell activating factor (BAFF), a member of the tumor necrosis factor family, serves as a critical regulator of humoral immunity. By binding to specific receptors on the surface of B cells, BAFF regulates their survival, proliferation, differentiation and antibody production, thereby playing a key role in the pathogenesis of autoimmune kidney diseases. Elevated serum BAFF levels, reported across multiple autoimmune diseases, promote aberrant B cell activation and autoantibody production. This review systematically illustrates the biology and immunology of BAFF, and further explores the role of BAFF in those autoimmune kidney diseases, aiming to provide a comprehensive insight into the BAFF molecule.

Source: Renal Failure

DOI: 10.1080/0886022x.2025.2577164

Authors: Jing Wu, Zhaohui Li, Shanshan Zheng, Yipeng Liu, Na Zhao

Institutions: Shandong Provincial QianFoShan Hospital, Shandong First Medical University

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,306