Evaluation of heat shock protein 70, AMH, and key hormonal markers in cellular mechanisms of polycystic ovary syndrome
Year: 2025
Type: article
Study design: Observational Study
Abstract: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases characterized by hyperandrogenemia and anovulation. The present study aimed to estimate heat shock protein 70 (HSP-70) in PCOS patients. This case-control study involved 90 females aged 15 to 45 years, divided into two groups: 45 controls and 45 PCOS patients. Levels of HSP-70, anti-Müllerian hormone (AMH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, and testosterone were measured using enzyme-linked immunosorbent assay (ELISA). The study revealed a significant increase (p ≤ 0.01) in HSP-70 and AMH levels in PCOS patients compared to controls, with mean ± SD values of 16.49 ± 2.79 and 2386.14 ± 530.09, respectively. Hormonal parameters such as LH, testosterone, and prolactin were elevated, whereas FSH was decreased in PCOS patients. The findings suggest that elevated HSP-70 plays a key role in the pathogenesis of PCOS.
Source: Cellular and Molecular Biology
Authors: Ayat Salim Khaleel, Abeer Cheaid Yousif Al-Fatlawi, Wasan Ghazi Abood Al-Safi
Institution: University of Kerbala
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4416209664