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BALF gene expression profiling reveals a fibrosis associated innate immune activation bias in persistent post-COVID-19 ILD

Year: 2025
Type: article
Study design: Observational Study
Abstract: Survivors of COVID-19 can experience long-term lung complications. We compared bronchoalveolar lavage fluid (BALF) cells from patients who recovered from COVID-19 lung injury and those who experienced significant long term residual damage. A prominent gene expression profile of increased monocyte chemotaxis coupled to decreased T cell activation was observed in persistent fibrotic post-COVID-19 ILD. These findings suggest that prolonged activation of innate immunity and subdued adaptive immune responses may be associated with persistent post-COVID-19 ILD and pulmonary fibrosis.
DOI: 10.1152/ajplung.00243.2025
Authors: Katerina M. Antoniou, Eirini Vasarmidi, Alexandros Galaras, Marilena Lourou, Ioanna Argyriou, Dimitra Zevla, Nikoleta Bizymi, Christos Skiadas, Irini Lambiri, Pantelis Hatzis, Vassilis Aidinis, Nikolaos Tzanakis, Athol U. Wells, Eliza Tsitoura
Institutions: University of Crete, University Hospital of Heraklion, University of Thessaly, Alexander Fleming Biomedical Sciences Research Center, National Health Service, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, Royal Brompton Hospital
Language: English
Subfield: Neurology
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W4416212104
FWCI:
Cites: 55
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