Work

Primer investigation of RIG-I-like receptors expression in virus infection with the acute character

Year: 2025

Type: article

Abstract: This study investigates the expression of RIG-I-like receptors (RLRs) – RIG-I, MDA5, and LGP2 – in Lagovirus europaeus /GI.2 infections causing Rabbit Hemorrhagic Disease. Despite over 30 years of study, the acute pathogenesis remains incompletely understood. Lack of in vitro culture systems hampers vaccine development. The experiment, conducted on European rabbits, reveals a significant increase in RLR expression during infection, particularly in organs associated with severe pathology. The findings suggest a pivotal role for RLRs, especially RIG-I, in the host's defense against Lagovirus europaeus . Further research is needed to unravel the complete molecular pathway and associated factors, offering potential insights for therapeutic interventions.

Source: Innate Immunity

DOI: 10.1177/17534259251394124

Authors: Filip Lewandowski, Rafał Hrynkiewicz, Karolina Wiśniewska, Karolina Pierzynowska, Paulina Niedźwiedzka-Rystwej

Institutions: University of Szczecin, University of Gdańsk

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,650