Work

Effect of long-term heat strain on calcium signaling in the murine myocardium

Year: 2025

Type: article

Abstract: Prolonged environmental heat exposure threatens cardiovascular health, yet underlying mechanisms remain poorly defined. Here, we show that 24 h of heat strain altered cardiac calcium handling. Heat strain appeared to increase cytosolic calcium clearance via a CaMKII/CaM/phospholamban-mediated activation of sarco(endo)plasmic reticulum calcium (SERCA) and subsequent SR sequestration. Interestingly, decreased PKA phosphorylation may be suggestive of blunted β-adrenergic stimulation. These findings implicate calcium dysregulation as a key contributor to myocardial stress during sustained heat exposure.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00616.2025

Authors: Melissa Roths, Joshua T. Selsby

Institution: Iowa State University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Food and Agriculture