Work

Basil ( Ocimum basilicum ) to Alleviate Anxiety in Patients With Major Depressive Disorder: A Randomized Placebo‐Controlled Clinical Trial

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: BACKGROUND: Major depressive disorder (MDD) is a widespread global mood disorder, often accompanied by anxiety as a common symptom. This study assessed the effectiveness of basil (Ocimum basilicum) syrup in alleviating anxiety in patients with depression. METHODS: A randomized single-blinded clinical trial was conducted at Dastgheib Psychiatric Clinic, Fasa University of Medical Sciences. Sixty participants were randomly assigned to receive either basil syrup or a placebo for 4 weeks. Anxiety and depression were assessed using the Hamilton Anxiety Rating Scale (HAM-A) and Beck Depression Inventory (BDI), respectively, before and after the intervention. RESULTS: The basil group showed significant reductions in HAM-A and BDI scores compared to the placebo group (p value < 0.05). CONCLUSION: Basil syrup could reduce anxiety in patients with MDD. However, further studies with a larger sample size and longer follow-up period are necessary. TRIAL REGISTRATION: IRCT20230318057752N1.

Source: Brain and Behavior

DOI: 10.1002/brb3.70994