Year: 2025
Type: article
Abstract: // Hoang Do 1 , Esther Asiamah 1 , Mayanijesu Olorife 1 , Arathi Pillai 1 , Sakshi Patel 1 , Ponniah Selvakumar 1 , Sidhartha D. Ray 2 and Ashakumary Lakshmikuttyamma 1 1 Department of Pharmaceutical Sciences, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107, USA 2 Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, NY 10036, USA Correspondence to: Ashakumary Lakshmikuttyamma, email: [email protected] Keywords: cancer; gut microbiota; bifidobacterium Received: June 16, 2025 Accepted: October 22, 2025 Published: November 14, 2025 Copyright: © 2025 Do et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Bifidobacterium has captured major attention recently because of its health benefits and extensive research highlighting its potential in cancer treatment and prevention. Evidence suggests that bifidobacterium can actively fight against various types of cancer, including those of the colon, lungs, breast, and stomach. Research indicates that several species of bifidobacterium can potentiate the action of chemotherapy, immunotherapy and radiation therapy in battling tumors, and reducing their adverse effects. Bifidobacteria shows its multipronged effect by modulating various immunomodulatory and inflammatory signaling pathways, potentially leading to the suppression of tumor growth. Moreover, different species of bifidobacteria are known to regulate signaling molecules involved in promoting apoptosis. In addition, bifidobacteria have an impact on the regulation of diverse microRNAs. The anticancer properties of bifidobacterium may also stem from its ability to detoxify carcinogens and transform dietary elements. This review also covers how dietary factors can influence the prevalence of bifidobacterium in the gut, further affecting its anticancer capabilities.
Source: Oncotarget
Authors: Hoang Do, Esther Asiamah, Mayanijesu Olorife, Arathi Pillai, Sakshi Patel, Ponniah Selvakumar, Sidhartha D. Ray, Ashakumary Lakshmikuttyamma
Institutions: Thomas Jefferson University, Touro College
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4416222245