A Lavandula angustifolia flower extract and dipeptide‐4 blend modulates oxidative, glycative, autophagic and circadian pathways in human skin models
Year: 2025
Type: article
Abstract: OBJECTIVE: This research assesses a novel cosmetic ingredient blending Lavandula angustifolia (lavender) flower extract and dipeptide-4 (LA-DP4, hereafter 'the blend'), for its potential to mitigate oxidative and glycation damage, boost autophagy and regulate circadian rhythms. METHODS: Using fibroblast, full-thickness skin models and ex vivo human skin, we measured markers like phosphorylated H2AX (γ-H2AX), reactive oxygen species (ROS), ATP, superoxide dismutase (SOD) and advanced glycation end products (AGEs), alongside effects on autophagic markers, melatonin production and extracellular matrix components. RESULTS: The blend significantly reduced γ-H2AX and ROS levels in UVA-stimulated fibroblasts, enhanced ATP and SOD levels, decreased AGEs in ex vivo tissues and improved tissue morphology in full-thickness models. Notably, it increased melatonin production and autophagic markers LC3a and LC3b, indicating a comprehensive role in skin health. CONCLUSION: The blend addresses skin ageing by offering multifaceted benefits: antioxidant, anti-glycation, autophagy enhancement and melatonin production, marking a pioneering contribution to cosmetic ingredients that significantly boost melatonin production. Our findings advance the understanding of in vitro and ex vivo efficacy testing methods for these properties, aiding cosmeceutical development.
DOI: 10.1111/ics.70041
Authors: Lina Wang, Yuxuan Wu, Huiping Hu, Yanan Li, Peiwen Sun
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,570
OpenAlex ID: W4416224721