Work

Multiorgan Dysfunction in Severe Acute Pancreatitis: A Case of Septic Shock, Renal Cortical Necrosis, and Takotsubo Cardiomyopathy

Year: 2025

Type: article

Abstract: Introduction: Severe acute pancreatitis (AP) may evolve rapidly into systemic inflammatory response syndrome and multiorgan dysfunction syndrome, posing significant management challenges. Case Presentation: We present a rare and complex case of severe AP complicated by septic shock, bilateral renal cortical necrosis (RCN), and Takotsubo cardiomyopathy (TTC). Septic shock contributed to profound hemodynamic instability, while RCN - a rare and often fatal form of acute kidney injury - added to the severity of renal dysfunction. Concurrent TTC, likely precipitated by catecholamine surges during critical illness, led to transient myocardial dysfunction. Conclusion: This case highlights the importance of early recognition, a multidisciplinary approach, and advanced critical care strategies, including SLED with hemoadsorptive filters, to improve outcomes in patients with severe AP complicated by rare systemic manifestations.

Source: Case Reports in Gastroenterology

DOI: 10.1159/000548734

Authors: Bhavin Patel, Rachana Patel, Nisarg Hajariwala, Divya Sharma, Yogesh Bhargava, Parag Rana

Institutions: Bhailal Amin General Hospital, Suamandeep Vidyapeeth University

Language: English

Topic: Pancreatitis Pathology and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030