B-cell maturation antigen targeted PET/CT imaging in multiple myeloma: a first-in-human study
Year: 2025
Type: article
Abstract: B-cell maturation antigen (BCMA)-targeted positron emission tomography/computed tomography (PET/CT) represents a promising tool for the management of multiple myeloma, enabling noninvasive and quantitative evaluation across different disease stages. This novel technique specifically addresses two major diagnostic challenges: the limited specificity of conventional 18 F-FDG PET/CT and the focal sampling constraints of bone marrow biopsies. In this prospective study, a 68 Ga-labeled nanobody-based BCMA tracer demonstrated improved detection compared with 18 F-FDG PET/CT, effectively visualizing para-medullary, extra-medullary and medullary lesions, as well as minimal residual disease (MRD). The tracer also reflected dynamic changes in BCMA expression associated with treatment response, underscoring its potential utility for guiding BCMA-targeted interventions, particularly in the era of chimeric antigen receptor T-cell (CAR-T) treatment. These preliminary findings support the potential of BCMA immunoPET as a comprehensive, noninvasive modality for MM evaluation and warrant validation in larger, prospective clinical trials.
Source: Journal of Hematology & Oncology
Authors: Tingfei Gu, Zhao Chen, Tianyao Wang, Yujun Dong, Lei Kang
Institution: Peking University First Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,990
Funders: Peking University First Hospital, National Natural Science Foundation of China, China Postdoctoral Science Foundation, Peking University, Beijing Municipal Science and Technology Commission, National Science and Technology Major Project, Beijing Nova Program, National Key Research and Development Program of China
OpenAlex ID: W4416225428