Work

Palladium‐Catalyzed Chemoselective Direct Arylation of Polyfluoroarenes With Chloroaryl Triflates at the C–Cl Bond

Year: 2025

Type: article

Abstract: This study describes a palladium-catalyzed chemoselective direct arylation of polyfluoroarenes with chloro(hetero)aryl triflates, achieving site-selective functionalization at the C-Cl bond for the first time. The recently developed alkyl-pyrazole-based phosphine ligand (BirdPhos) proved essential for the success of this transformation, affording excellent yields with high chemoselectivity. Moreover, the catalytic system enables the efficient synthesis of a broad range of functionalized polyfluoroarene derivatives under mild, additive-free conditions. Notably, the reaction retains the triflate group in the products, providing a versatile functional handle for further derivatization and highlighting the broad applicability and synthetic utility of this method.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202500949

Authors: Zifang Peng, Changxue Gu, On Ying Yuen, Shan Shan Ng, Chau Ming So

Institution: Hong Kong Polytechnic University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Hong Kong Polytechnic University

Award: G8725477670