Effect of 3% diquafosol sodium eye drops on the prediction of intraocular lens power in predisposition to dry eye patients scheduled for cataract surgery: a prospective, observational study
Year: 2025
Type: article
Abstract: Purpose: To investigate the effect of 3% diquafosol sodium eye drops (DQS) on intraocular lens (IOL) power calculated by multiple common formulas before surgery in patients with predisposition to dry eye (p-DE) scheduled for cataract surgery. Methods: This prospective, observational study included patients scheduled for cataract surgery at the Ophthalmology Clinic of Jiangsu Provincial People's Hospital between July 2022 and July 2023. A total of 50 eyes underwent repeated measurements to assess instrument stability, while 91 were divided into p-DE and control groups with mean tear break-up time (mBUT) <10 s and mBUT ≥10 s, respectively. Biological indexes were measured 5 min after DQS use in both p-DE and control groups. Results: > 0.05). Combined correlation analysis and logistic regression analysis revealed that changes in steep keratometry and TMH after treatment with DQS eye drops were the main factors affecting IOL power change. Additionally, mBUT before DQS use was identified as the primary factor affecting TFS change. Conclusion: Use of 3% DQS induces changes in intraocular lens power by affecting steep keratometry values, with such change being more significant in predisposition to dry eyes and warranting attention. When planning cataract surgery, it is recommended to prioritize the Barrett Universal II formula for IOL power calculation.
Source: Frontiers in Medicine
Authors: Na Su, Lexin Ge, Nianfeng Tang, Junjie Shan, Wen Fan, Songtao Yuan
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G4379198102, G738602426
OpenAlex ID: W4416228249