Work

Non-invasive tracking of rAAV-mediated gene expression in the liver through a genetically encoded MRI reporter gene

Year: 2025

Type: article

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2025.11.014

Authors: Zinia Mohanta, Aruna Singh, Hernando Lopez-Bertoni, Sophie Sall, Julia Stabinska, Irini Manoli, Hilary Vernon, Charles P. Venditti, Assaf A. Gilad, Michael T. McMahon

Institutions: Kennedy Krieger Institute, Johns Hopkins University, Johns Hopkins Medicine, National Institutes of Health, National Human Genome Research Institute, Reichman University, Scojen Institute for Synthetic Biology, Michigan State University

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: United States - Israel Binational Science Foundation, National Human Genome Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering

Awards: G2837935397, Evolution and optimization of synthetic <READ/WRITE> function from and into cells using genetic programming, Developing MRI contrast agents to detect progression in renal disease as a consequence of acidema, G8333881528, Investigations of Methylmalonic Acidemia and Related Disorders, Clinically Translatable MRI Reporter Genes and Imaging Methods with Ultra-High Specificity and Sensitivity, Molecular determinants of cellular heterogeneity and therapeutic resistance in GBM.

OpenAlex ID: W4416229278

FWCI: 0.584

Cites: 49

Cited by: 1

Related to: 10